Berberine is an active constituent found in a variety of species of plants. Newer studies have found berberine has biological effects in several pathways in the body, indicating it may be a potential treatment for metabolic syndrome. Metabolic syndrome is hypothesized as beginning with an accumulation of lipids in nonadipose tissues, known as nonalcoholic fatty liver disease (NAFLD). Berberine also has studies supporting its ability to reduce symptoms associated with NAFLD, as well as showing significant antidiabetic effects and lipid-lowering capability. Historically, berberine has been used for its antimicrobial activity, as berberine is active against a wide range of organisms including bacterial viruses, fungi, helminths, and chlamydia.

Ingredients
Each non-GMO vegetable capsule contains:
Berberine hydrochloride    300 mg
Goldenseal (Hydrastis canadensis) root    150 mg

All ingredients listed for this product lot number have been validated by a third-party laboratory for identity, potency, and purity.

Suggested Use
Adults: Take 1 capsule three times daily or as directed by your health-care practitioner. Consult a health-care practitioner for use beyond 3 months.

Contains no
Preservatives, artificial flavour or colour, dairy, wheat, gluten, yeast, soy, citrus, or eggs.

SAFETY AND SIDE EFFECTS
There is a long history of safe usage of berberine clinically. However, some adverse effects have been reported, including gastrointestinal concerns, allergic skin reactions, and arrhythmia.[1] There are some reports that indicate berberine may induce apoptosis in hepatoma cells; however, these cytotoxic effects were not seen in healthy hepatocytes.[1]
In a recent study, berberine supplemented in oral dosages of 500 mg three times per day was associated with gastrointestinal symptoms in 34.5% of participants.[3] However, at the reduced dose of 300 mg of berberine three times per day, gastrointestinal side effects were eliminated while observing similar beneficial effect on glucose and lipid control. For this reason and optimal patient safety, Berberine SAP is dosed at 300 mg per capsule of berberine hydrochloride.

WARNING: If you are pregnant or breast-feeding, consult your health-care practitioner before taking this product.