Avoid prolonged exposure to sunlight, ultraviolet light (UV) or UV therapy. Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you are taking digoxin or medications such as anti-anxiety and/or antidepressant, seizure, antihistamines, bronchodilators, muscle relaxants and/or opiates; if you have a liver disorder or if you have diabetes. Do not use if you are pregnant or breastfeeding, or if you are taking medications for anti-cancer, blood thinners, antidepressants (e.g. selective serotonin reuptake inhibitors (SSRI)), anti-HIV agents, cardiovascular, immunosuppressants, and/ or contraceptive, if you have hormone sensitive conditions such as uterine, endometrial, breast or ovarian cancer as well as endometriosis and uterine fibroids, if you have a protein S deficiency as wild yam may increase the risk of thrombosis, or a seizure disorder (e.g. epilepsy). Hypersensitivity, such as an allergy, has been known to occur; and some people may experience mild gastrointestinal disturbances, nausea, insomnia, restlessness and/or headaches in which case, discontinue use.